(0717) Receipt of Postoperative Radiotherapy at Different Facility in Sinonasal Squamous Cell Carcinoma Patients

Introduction: Changing location of postoperative radiotherapy (PORT) after surgical resection at high volume facilities (HVF) is associated with worse survival in various head and neck squamous cell carcinomas (SCC). We evaluate this relationship for sinonasal SCC (SSCC) patients.

Methods: The 2004-2016 National Cancer Database was queried for all cases of adult SSCC treated with surgery and PORT with or without adjuvant chemotherapy. Patients with multiple cancer diagnoses or with unknown location for receipt of PORT were excluded. Centers with greater than 95th percentile annual case volume were classified as HVF while the remainder were grouped as low volume facility (LVF).

Results: A total of 3,033 patients met inclusion criteria, of which 163 (5.4%) were treated at HVF. HVF saw higher rates of clinical T4 (52.1% vs 32.9%, p < 0.001) disease. There was no significant difference in 5-year overall survival (5-OS) between LVF and HVF (57.1% vs 57%, p = 0.998). A total of 905 patients (29.8%) changed facilities for PORT. Patients treated at HVF changed location for PORT at greater rates (52.1% vs 28.6%, p < 0.001). Time to initiate PORT was not significantly longer between patients that changed or remained at their surgical treatment facility (56.15 vs 52.15 days p = 0.169). Changing treatment for PORT from a HVF was not significantly associated with worse 5-OS (48.7% vs 66.6%, p = 0.124) than remaining at the same facility.

Conclusions: Patients treated at HVF present with more advanced SSCC. For patients treated surgically at HVF, changing facility for receipt of PORT was not significantly associated with survival.