(0327) Predisposing Factors of Rhino-Orbital-Cerebral-Mucormycosis in Patients With COVID-19 Infection

Introduction: The predisposing factors of invasive fungal disease in COVID-19 infection are still debatable because of the limited human understanding of the virus with the current literature. In this study, we have tried to correlate the various predisposing factors influencing the clinical profile and treatment outcomes in patients with Covid associated mucormycosis (CAM).

Methods: It is a retrospective analysis of cases of CAM during the second wave of COVID-19 infection, which was managed in the department of otorhinolaryngology from December 1, 2020, to June 10, 2021. The detailed clinical, radiological and management of patients with CAM were collected, recorded, evaluated and correlated with the predisposing factors.

Results: Of the total 46 patients, 44 (95.65%) were diabetic, and 41 patients had a previous history of steroid intake. When clinical parameters were compared between blood sugar \200 mg/dl and 200 mg/dl, the old and newly diagnosed diabetes mellitus in patients with CAM, there was no significant differences in any of the above clinical parameters (p = 0.05), except the hospital stay (p = 0.004).

Conclusions: Steroid intake in patients with coexisting DM associated with CAM is considered the most important factor for the development of the CAM. There was are no significant difference in any of the clinical/treatment outcomes in patients with CAM with respect to the initial blood sugar, except for the hospital stay. A large sample size with a long-term follow-up period may be needed for a better understanding of common predisposing factors for the development of CAM.