(0408) Incident Predictors of Thyroid Cancer Subtypes: An Analysis of the National Childhood Cancer Registry Database

Introduction: This project’s goal was to analyze and compare population data for papillary and follicular thyroid cancer to determine at risk populations for further investigation of novel exposures and potential causes associated with the disparity between incident rates of thyroid cancers.

Methods: The NCCR database identified patients diagnosed with thyroid cancer from 1975-2020. Demographic, pathologic subtype, and survival trends were analyzed by year over year trendline progression followed with a thorough literature review of known and theorized risk factors for thyroid cancer development in discussion.

Results: Calculated annual percent change for follicular thyroid cancer found a noticeable difference in incidence rate between 1997-2009 amongst male and female patients with net 7.5% difference in reported rate per 100,000 with men (12.1%) more than doubling the reported percent change rate for women (4.6%). Analysis for papillary thyroid cancer however found no significant difference between male and female rates with a slight, statistically insignificant difference of 0.3% favoring men (10.9%) over women (10.6%). When analyzed along racial or age demographic lines no variations between historic annual percent changes to analyzed data sets were observed.

Conclusions: Comparing the incidence rates between both papillary and follicular subtypes of thyroid cancer revealed an asymmetric distribution between gender for reported cases of follicular thyroid cancer between the years of 2000-2010. Both subtypes share the same risk factors of family history, genetic family syndromes and radiation exposure, with radiation therapy at a young age being the leading risk factor for both cancer subtypes. Despite the shared risk factors between subtypes, only the follicular subtype favored an increased incidence amongst men suggesting additional factors at play. A literature analysis will compile and compare suspected environmental risk factors for males developing follicular thyroid cancer