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Scientific Oral Presentations

Laryngology/Broncho-Esophagology

Session: Scientific Oral Presentations 4 - Laryngology/Broncho-Esophagology

Association of Extrapulmonary Chronic Cough With Psychiatric Comorbidities

Tuesday, October 1, 2024
10:24 AM – 10:30 AM EDT
Location: MBCC, 224
Disclosure(s):
William A. Strober, MD, MSCI:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Molly N. Huston, MD:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Matthew L. Rohlfing, MD:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Introduction: Chronic cough is a highly prevalent condition that significantly reduces quality of life, but our current understanding of the association between chronic cough and psychiatric comorbidities is limited. This study aims to describe the association between extrapulmonary chronic cough (ECC) and psychiatric comorbidities using a validated national database analysis.

Methods: The National Health and Nutrition Examination Survey (NHANES), a program of studies designed to assess the health and nutritional status of adults in the United States, was used to identify patients with ECC between 2007-2012. Participant demographic information and diagnoses were obtained from the results of these surveys. Prevalence of ECC and psychiatric comorbidities was assessed. Multivariable logistic regression was used to assess associations between ECC and psychiatric comorbidities after controlling for several confounding factors including demographic variables and other comorbidities known to be associated with chronic cough.

Results: This study included a total of 9,941 participants, corresponding to a weighted total of 123,419,943 participants. Of these, 5,753,420 (4.6%) had pulmonary-related chronic cough, 7,947,586 (6.4%) had ECC, and 109,718,937 (88.9%) had no chronic cough. After controlling for several demographic variables and comorbidities associated with chronic cough, there was a clinically and statistically significant association between ECC and depression severity (PHQ-9 categories) (mild OR: 1.7 [95% CI: 1.2-2.2], moderate OR: 1.9 [95% CI: 1.4-3.2], moderately severe OR: 1.8 [95% CI: 0.9-3.3], severe OR: 3.5 [95% CI: 1.2-10.0]). There was also a strong association between ECC and anxiety (OR: 1.9 [95% CI: 1.4-2.5]).

Conclusions: There are strong associations between ECC and both depression severity and anxiety. Physicians should consider the possible bidirectional impact of psychiatric comorbidities and chronic cough. Based on these findings, future studies should be conducted to gain a deeper understanding of this relationship.

    Presenting Author(s)

  • William A. Strober, MD, MSCI

    Resident Physician
    Washington University/BJH/SLCH Consortium
    Saint Louis, MO, United States

    Disclosure(s):

    faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

    • Co-Author(s)

  • DK

    Dorina Kallogjeri, MD, MPH

    Assistant Professor
    Department of Otolaryngology-Head & Neck Surgery, Washington University/B-JH/SLCH Consortium
    St Louis, Missouri, United States

    Disclosure information not submitted.

  • MH

    Molly N. Huston, MD

    Assistant Professor
    Washington University in St. Louis
    Saint Louis, MO, United States

    Disclosure(s):

    faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

  • MR

    Matthew L. Rohlfing, MD

    Assistant Professor
    Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine
    St. Louis, MO, United States

    Disclosure(s):

    faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

    • Senior Author(s)

  • Jay F. Piccirillo, MD

    Professor, Vice Chair for Research
    Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine
    St. Louis, MO, United States

    Disclosure information not submitted.