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Scientific Oral Presentations

Laryngology/Broncho-Esophagology

Session: Scientific Oral Presentations 3 - Laryngology/Broncho-Esophagology

Impact of Breathing Techniques on Aerosol Drug Delivery to Laryngopharynx

Monday, September 30, 2024
10:24 AM – 10:30 AM EDT
Location: MBCC, 224
Disclosure(s):
Shamudra Dey, BSc:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Aditya Vishnu Jadcherla, BS:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Nikki Johnston, PhD:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Jonathan M. Bock, MD:

faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

Introduction: Dry powder inhalers (DPIs) are under development to treat laryngopharyngeal reflux, a disease for which no effective therapeutic drug exists. DPIs were originally developed to treat lung diseases and designed to minimize deposition in the upper airways and maximize deposition in the lungs. This study investigated the impact of particle size and breathing technique (deep vs shallow inhalation) on the dose delivered to the laryngopharynx using computational fluid dynamics.

Methods: A 3-dimensional model of the airways (mouth to main bronchi) was created from magnetic resonance imaging of a healthy adult. Transient airflow and particle transport simulations were performed in ANSYS software using the k-omega turbulence model. The amplitude of the sinusoidal breathing profile was varied to investigate how the breathing technique (deep vs shallow inhalation) affected the regional doses. A log-normal particle size distribution was assumed with a mass median aerodynamic diameter of 10 µm for DPI-1 (representing a DPI optimized for laryngopharynx deposition) or 3 µm for DPI-2 (representing a commercially available DPI).

Results: Particle size distribution had a major impact with laryngopharyngeal deposition decreasing from 31% for DPI-1 to 10% for DPI-2 for a normal inhalation. Breathing technique had a significant impact on laryngopharyngeal deposition for DPI-2 (12% for deep inhalation vs 6.5% for shallow inhalation), but had a negligible effect for DPI-1 (29.4% for deep inhalation vs 30.3% for shallow inhalation).

Conclusions: Our simulations suggest that particle size distribution has a bigger impact on the laryngopharyngeal dose than the breathing technique. Additional studies are needed to test this prediction in a larger cohort.

    Co-Author(s)

  • Shamudra Dey, BSc

    Graduate Research Assistant
    Medical College of Wisconsin
    Milwaukee, Wisconsin, United States

    Disclosure(s):

    faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

    • Presenting Author(s)

  • AJ

    Aditya Vishnu Jadcherla, BS

    Medical Student
    Medical College of Wisconsin
    Milwaukee, WI, United States

    Disclosure(s):

    faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

    • Co-Author(s)

  • Nikki Johnston, PhD

    Professor
    Medical College of Wisconsin
    Milwaukee, WI, United States

    Disclosure(s):

    faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

  • Jonathan M. Bock, MD

    Professor
    Froedtert & Medical College of Wisconsin
    Milwaukee, WI, United States

    Disclosure(s):

    faculty for this accredited education activity has no relationship(s) with ineligible companies to disclose.

    • Senior Author(s)

  • GG

    Guilherme J. M Garcia, PhD

    Assistant Professor
    Medical College of Wisconsin
    Milwaukee, WI, United States

    Disclosure information not submitted.