(1228) Role of Platelet-Rich Plasma in Treatment of Post-COVID-19 Anosmia

Introduction: The impairment of the sense of smell, known as olfactory dysfunction, is a common condition that impacts around 20% of the overall population. The incidence of Olfactory Dysfunction has significantly risen, ranging from 30% to 86% among patients, after the emergence of the COVID-19 pandemic in 2019.
Aim of the work:-Evaluation of effect of platelet-rich plasma alone & effect of platelet-rich plasma with Dexamethasone in treatment of Post COVID-19 Olfactory Dysfunction.

Methods: The study is prospective, The research participants were recruited from patients who suffered from post COVID-19 Anosmia in the Minia university hospital outpatient clinic.from 2021 to 2023. The patients were classified randomly into two groups, with 25 patients in every group. Group A received platelet-rich plasma only in the form of injection in the olfactory area. Group B received platelet-rich plasma & Dexamethasone in the form of injection in the olfactory area.

The patients subjected to, history taking, general examination, ORL examination and Butanol Threshold test for diagnosis of Anosmia.

Results: The mean age for patients of Prp only group was 31.96 ± 8.32 and it was 34.36 ± 8.70 for patients of Prp and dexa group, and this was statistically insignificant. The median of Butanol Threshold test before for patients of Prp only group was 3 (1.5 – 4) and it was 3 (1 – 4) for patients of Prp and dexa group, and this was statistically insignificant. There was highly statistically significant increase among butanol threshold test after treatment than butanol threshold test before treatment in the Prp only group as well as in Prp and dexa group. The median of Butanol Threshold test after for patients of Prp only group was 3 (1.5 – 5) and it was 4 (2 – 5) for patients of Prp and dexa group, and this was statistically insignificant.

Conclusions: Our findings indicated that the combination therapy of PRP and Dexamethasone significantly reduced the duration of anosmia in patients compared to PRP alone, suggesting its potential as a more effective treatment option.